Botox® Cosmetic, Dysport® Injection

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Summary:
Botox® Cosmetic, Dysport®, BTX-A injections to reduce Glabella Frown Lines, Crow’s Feet, and Horizontal Forehead Lines

Description:

   The application of Botox® Cosmetic, Dysport®, BTX-A in aesthetic facial procedures is the introduction of minute quantities of a substance to relax and reduce the tension of specific muscles of the face which control facial expression bringing about a reduction of wrinkles.

   One of the ways by which we communicate our emotion, and the way we feel about things to another person, is by facial expression. The way we change our facial expression is by contracting muscles below the skin of our face to move the overlying skin in various directions.

   Depending on the muscles contracted, we create wrinkles like glabella frown lines when we are concentrating, crow's feet when we smile, and horizontal forehead lines when we are surprised.

   When we are young, our skin is soft and supple, and easily springs back to its original shape when the muscle relaxes after contracting. However, as age catches up, the skin becomes harder and stiffer, and tends to retain the crease lines. As happens with repeated crumpling of paper, the crease lines become deeper and more prominent over time.

   Reducing the tension in these muscles, prevents our skin from being repeatedly damaged, and thus allow us to retain our youthful appearance for a much greater length of time.

Want to know more or talk to a doctor? Visit Shim Clinic, Singapore

External Links:
BOTOX® Cosmetic Injections for Frown Lines and Brow Furrows: BOTOX® Cosmetic Official Web Site
Ipsen Limited UK - Dysport®
Botulinum toxin - Wikipedia, the free encyclopedia
Botox: Definition from Answers.com
HowStuffWorks "How Botox Works"
Botox -- Britannica Online Encyclopedia
BOTOX® Cosmetic - Plastic Surgery Portal

Latest News:

Fda issues complete response letter to ipsen for dysport® biologics license application for treatment of cervical dystonia
Sat, 03 Jan 2009 08:00:00 +0100 | Health News from Medical News Today
Ipsen (Paris:IPN) today announced that the US Food and Drug Administration (FDA) issued a Complete Response Letter for its Biologics License Application (BLA) for its Botulinum toxin Type A, Dysport®. The application, submitted by the Group in late 2007, seeks approval to market Dysport® for the treatment of cervical dystonia. (Source: Health News from Medical News Today)

Botulinum toxin (dysport) treatment of the spastic gastrocnemius muscle in children with cerebral palsy: a randomized trial comparing two injection volumes.
Thu, 01 Jan 2009 05:00:00 +0100 | Clinical Rehabilitation
Conclusions: A high-volume preparation of Dysport is more effective than a low volume in reducing spasticity in the gastrocnemius muscle. PMID: 19114438 [PubMed - in process] (Source: Clinical Rehabilitation)

The trend for 'baby' botox: 10 of the best practitioners
Wed, 31 Dec 2008 11:16:46 +0100 | Telegraph Health
Alice HartDavis's guide to the best Botox treatments. (Source: Telegraph Health)

Fda approves allergan's drug for longer eyelashes
Tue, 30 Dec 2008 02:29:09 +0100 | Medscape Medical News Headlines
Allergan Inc, maker of Botox, said on Friday that the U.S. Food and Drug Administration has approved its eyelash-thickening drug Latisse. Reuters Health Information (Source: Medscape Medical News Headlines)

Surgeon offers layaway for cosmetic treatments
Mon, 29 Dec 2008 12:44:47 +0100 | FOXNews.com
Scottsdale cosmetic surgeon Semone Rochlin is offering patients a "layaway plan for budgeted beauty" to help them cope with the economic crisis and the difficulty of getting loans for treatments such as tummy tucks and facial Botox injections. (Source: FOXNews.com)

Fda approves allergan's drug for longer eyelashes
Fri, 26 Dec 2008 19:59:43 +0100 | Reuters: Health
BOSTON (Reuters) - Allergan Inc, the maker of Botox, said on Friday that the U.S. Food and Drug Administration has approved its eyelash-thickening drug Latisse. (Source: Reuters: Health)

Botulinum toxin useful for masseteric muscle hypertrophy
Fri, 26 Dec 2008 16:42:55 +0100 | Medscape Medical News Headlines
Findings from a small case series suggest that intramuscular injections of botulinum toxin type A are an effective treatment for masseteric muscle hypertrophy, an uncommon condition of unknown etiology involving unilateral or bilateral swelling at the mandibular angle. Reuters Health Information (Source: Medscape Medical News Headlines)

Botulinum toxin provides new treatment option
Thu, 25 Dec 2008 09:00:00 +0100 | Health News from Medical News Today
For patients with an uncommon condition causing a swollen appearance of the lower face, treatment with botulinum toxin type A (Botox) provides an effective alternative to plastic surgery, according to a study in the November Journal of Craniofacial Surgery. (Source: Health News from Medical News Today)

Most people would not like botox treatment as a christmas present
Wed, 24 Dec 2008 12:00:00 +0100 | Health News from Medical News Today
Credit crunch stress may add a few wrinkles to the most youthful of complexions this Christmas, but think twice before you include a course of Botox treatment in your loved one's stocking, says Which? (Which? is a UK consumer magazine). (Source: Health News from Medical News Today)

Lower facial contouring with botulinum toxin type a.
Wed, 24 Dec 2008 10:11:06 +0100 | Journal of Craniofacial Surgery
Page: 1613DOI: 10.1097/SCS.0b013e31818973c8Authors: Tartaro, Gianpaolo MD, FACS; Rauso, Raffaele MD; Santagata, Mario MD; Santillo, Vincenzo MD; Itro, Angelo MD, DDS (Source: Journal of Craniofacial Surgery)

Which? bid to stop online botox promotions
Wed, 24 Dec 2008 10:00:00 +0100 | Dermatology News From Medical News Today
eBay has agreed to remove illegal Botox adverts* from its popular site after Which? discovered over 240 instances of unlawful advertising of the product in just five days**. Sixteen companies and individuals were found advertising the prescription only medicine to the public, with many unaware they were breaking the law***. (Source: Dermatology News From Medical News Today)

Botox remains popular in downturn
Tue, 23 Dec 2008 02:51:34 +0100 | WSJ.com: Health
Despite the dismal economy, many people are still spending hundreds or thousands of dollars on appearance-enhancing treatments like Botox. (Source: WSJ.com: Health)

Skin deep: putting vanity on hold
Thu, 18 Dec 2008 04:53:36 +0100 | NYT > Health
As the country plunges into recession, will financial hardship demote the pursuit of physical perfection? (Source: NYT > Health)

Delayed onset of brown–sequard syndrome involving upper extremity pain
Tue, 16 Dec 2008 05:00:00 +0100 | Pain Practice
Report of a case: A 60-year-old white male with a history of C3[ndash]C4 spinal cord injury with subsequent C3[ndash]C4 fusion complained of right upper extremity painful spasms of 2 years duration with associated hyperspasticity, motor weakness and poor positional and vibrational sense. The patient was diagnosed with Brown[ndash]Sequard syndrome (BSS) and treated with botulinum toxin type A injections distributed into the affected muscle groups that provided substantial and lasting relief. This case is unique in that the patient's trauma occurred 28 years before the development of the BSS suggesting a slow evolution of the condition. (Source: Pain Practice)

Botulinum toxin type a -- treatment of a patient with multiple cutaneous piloleiomyomas
Mon, 15 Dec 2008 14:57:48 +0100 | Dermatology
Dermatology 2009;218:44-47 (DOI:10.1159/000173695) (Source: Dermatology)

Research letters: intrafollicular orifice injection technique for botulinum toxin type a
Mon, 15 Dec 2008 05:00:00 +0100 | Archives of Dermatology
(Source: Archives of Dermatology)

Youthfulness an american obsession
Sat, 06 Dec 2008 19:05:21 +0100 | WDSU.com - Health
As the baby boomers march toward retirement, Botox, wrinkle fillers and hormones of various kinds have become big business. (Source: WDSU.com - Health)

Perspective of botox for treatment of male lower urinary tract symptoms.
Fri, 05 Dec 2008 08:06:54 +0100 | Current Opinion in Urology
Page: 20DOI: 10.1097/MOU.0b013e328316c33fAuthors: Ilie, Cristian P a; Chancellor, Michael B b (Source: Current Opinion in Urology)

The acupuncture facelift
Thu, 04 Dec 2008 13:26:27 +0100 | Telegraph Health
An acupuncture facelift gives Alice HartDavis reason to smile. (Source: Telegraph Health)

Relationship between various clinical outcome assessments in patients with blepharospasm
Wed, 03 Dec 2008 05:00:00 +0100 | Movement Disorders
The objective was to analyze the metric properties of the Jankovic Rating Scale (JRS) and a self-rating patient response outcome scale, the Blepharospasm Disability Index (BSDI©), in blepharospasm patients. Data from a randomized, double-blind, active-control clinical trial in 300 patients with blepharospasm treated with either botulinum toxin type A (Botox®) or NT201 (Xeomin®) were used to evaluate the metric properties of the JRS and the BSDI compared with the Patient Evaluation of Global Response (PEGR) and Global Assessment Scale (GAS). The internal consistency of the BSDI was high, Cronbach's Alpha = 0.88, and the retest reliability of the BSDI single items was adequate, Spearman's rank coefficient = 0.453 < r < 0.595. The correlation between JRS sum score and BSDI weighted mean sc...

[early care and botulinum toxin. our experience in the 21st century]
Mon, 01 Dec 2008 17:19:21 +0100 | Revista de Neurologia
CONCLUSIONS: The children, parents and professionals involved all view EI and BTA with satisfaction. Neuropaediatrics is one of the medical specialties that are best suited to child development and early intervention centres (CDIAT). The neuropaediatrician participates in all the stages of the EI: detection, diagnosis, information and intervention. He or she may act as the coordinating and homogenising element in EI, that is to say, as a link between CDIAT and health care services. Neuropaediatricians are also essential in EI training and education, in family training, information and awareness campaigns, primary care, social services and nurseries. Treatment with BTA cannot be viewed as an isolated technique, but instead as part of a programme in which physiotherapy, orthosis and sometime...

[botulinum toxin in infantile cerebral palsy]
Mon, 01 Dec 2008 17:19:21 +0100 | Revista de Neurologia
CONCLUSIONS: BTA is a good therapeutic option for treating children with CP, not only for the focal involvement but also as palliative treatment in children with diffuse involvement. PMID: 18767013 [PubMed - in process] (Source: Revista de Neurologia)

Safety of botulinum toxin type a in children younger than 2 years.
Mon, 24 Nov 2008 05:00:00 +0100 | European Journal of Paediatric Neurology
CONCLUSIONS: BoNT-A has a good safety profile in infants younger than 2years old. AEs are similar to those found in older children. PMID: 19036619 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)

Vegas doctor, wife convicted of using botox substitute
Fri, 21 Nov 2008 23:47:26 +0100 | CTV Health
A doctor and his wife have been convicted of treating patients with a Botox knockoff at their Las Vegas clinic. (Source: CTV Health)

Robotic therapy and botulinum toxin type a: a novel intervention approach for cerebral palsy.
Fri, 21 Nov 2008 08:13:11 +0100 | American Journal of Physical Medicine & Rehabilitation
Page: 1022DOI: 10.1097/PHM.0b013e31817fb346Authors: Fasoli, Susan E. ScD, OTR/L; Fragala-Pinkham, Maria PT, MS; Hughes, Richard PT, MS, NCS; Krebs, Hermano Igo PhD; Hogan, Neville PhD; Stein, Joel MD (Source: American Journal of Physical Medicine & Rehabilitation)

New botox treatment works on more than wrinkles
Thu, 20 Nov 2008 18:04:14 +0100 | WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire
Everyone knows about Botox, the wrinkle-reducer that's injected into the face to retain a youthful look. It turns out that the procedure now has a number of new uses. Botox can also reduce excessive sweating and relax facial muscles. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

Greater safety checks for cosmetic treatments urged
Wed, 19 Nov 2008 03:30:36 +0100 | Telegraph Health
Greater safety checks for 'skin filler' cosmetic treatments has been urged following reports of facial paralysis disfigurement and severe allergic reactions it has been disclosed. (Source: Telegraph Health)

Physicians coalition for injectable safety warns consumers about cosmetic injection discounts
Tue, 18 Nov 2008 09:00:00 +0100 | Dermatology News From Medical News Today
Bargains on consumer goods and services may be designed to encourage spending in tough economic times, however when related to cosmetic injections like Restylane, Juvederm or Botox, the multi-specialty Physicians Coalition for Injectable Safety warns that discounts raise a red flag. (Source: Dermatology News From Medical News Today)

The fountain of youth in a hand-held device [video]
Mon, 17 Nov 2008 15:41:19 +0100 | i21c Health
, 11/17/08 - Forget botox, or painful surgery, an Israeli company has developed a new radioactive skin renewal device that it claims can erase wrinkles, tighten sagging skin and even add collagen back to your face in a non invasive treatment that takes just 30 minutes week. Find out more in our Video-only story. More... (Source: i21c Health)

Administration of type a botulinum toxin after total hip replacement.
Thu, 13 Nov 2008 17:41:03 +0100 | European Journal of Physical and Rehabilitation Medicine
Authors: Bertoni M, Castagna A, Baricich A, Berti G, Lazzaretti S, Morandi C Pain after hip replacement is one of the most common problems during rehabilitation and is often the main obstacle in rehabilitation, even though it can often be controlled by localized cryotherapy and/or administration of analgesics. However, patients with positive anamnesis for hip arthritis and long-lasting pain may report persistence of symptoms for months after surgical intervention; often, in these patients, contractures and muscle retraction in the pelvic region are observed. The present study reports the case of a female patient who suffered from complications after total hip replacement (THR) for osteoarthritis. Due to severe pain in the gluteal region not responding to standard treatments the patient...

Asds 2008: clostridium botulinum type a toxin appears fast acting, long lasting in treating glabellar lines
Thu, 13 Nov 2008 03:05:13 +0100 | Medscape Dermatology Headlines
Two phase 3 studies show favorable outcomes for a new alternative to Botox. Medscape Medical News (Source: Medscape Dermatology Headlines)

Subcutaneous histamine versus botulinum toxin type a in migraine prophylaxis: a randomized, double-blind study
Wed, 12 Nov 2008 05:00:00 +0100 | European Journal of Neurology
Conclusions: This randomized study demonstrated that both histamine and BoNTA are similarly effective and well tolerated in reducing or eliminating headache in migraine prophylaxis. Low doses of histamine applied subcutaneously may represent a novel and effective therapeutic alternative in migraine patients and lay the clinical and pharmacological groundwork for the use of H3 agonist in migraine prophylaxis. (Source: European Journal of Neurology)

Migraine sufferers turn to botox
Tue, 11 Nov 2008 14:16:47 +0100 | WDSU.com - Health
Nasal sprays, pills and injections help some people who suffer migraines. But an anti-wrinkle treatment may also get people back to their lives. (Source: WDSU.com - Health)

It's the anti-wrinkle treatment linked to several deaths, so clinics wouldn't inject botox into a girl of 18... would they?
Tue, 11 Nov 2008 10:09:06 +0100 | the Mail online | Diet
Would cosmetic surgeons inject botox into a teenager's face? We sent North London student Ella Samoles-Little, 18, to find out. As she reveals in this disturbing report, Botox was just the tip of the iceberg. (Source: the Mail online | Diet)

It's the anti-wrinkle treatment linked to several deaths, so clinics wouldn't inject botox into a girl of 18... would they?
Tue, 11 Nov 2008 02:01:04 +0100 | the Mail online | Health
Would cosmetic surgeons inject botox into a teenager's face? We sent North London student Ella Samoles-Little, 18, to find out. As she reveals in this disturbing report, Botox was just the tip of the iceberg. (Source: the Mail online | Health)

Subcutaneous botulinum toxin type a reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin.
Mon, 10 Nov 2008 05:00:00 +0100 | Pain
Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin. Pain. 2008 Nov 10; Authors: Gazerani P, Pedersen NS, Staahl C, Drewes AM, Arendt-Nielsen L The present human study aimed at investigating the effect of subcutaneous administration of Botulinum toxin type A (BoNT/A) on capsaicin-induced trigeminal pain, neurogenic inflammation and experimentally induced cutaneous pain modalities. Fourteen healthy males (26.3+/-2.6 years) were included in this double-blind and placebo-controlled trial. The subjects received subcutaneous BoNT/A (22.5U) and isotonic saline in the mirror sides of their forehead. Pain and neurogenic inflammation was induced by four intradermal injections of capsaicin (100mug/muL) (before, and days 1, 3...

Relief by botulinum toxin of lower urinary tract symptoms owing to benign prostatic hyperplasia: early and long-term results.
Fri, 07 Nov 2008 05:00:00 +0100 | Urology
CONCLUSIONS: Intraprostatic BT seems to be a promising approach to the treatment of BPH. It is safe, effective, well-tolerated, and not related to the patient's willingness to complete treatment. PMID: 18995889 [PubMed - as supplied by publisher] (Source: Urology)

Botox sales up by 300%
Fri, 07 Nov 2008 00:00:00 +0100 | Scotsman.com News - Health
DEMAND for Botox has soared almost 300 per cent in a year, the UK's largest provider of non-surgical treatments said yesterday. (Source: Scotsman.com News - Health)

Skin deep: in hard times, a cosmetic hard sell
Thu, 06 Nov 2008 04:52:59 +0100 | NYT > Health
Some doctors are eager to make a deal on Botox, and facial and body operations. (Source: NYT > Health)

Current evidence on the unit equivalence of different botulinum neurotoxin a formulations and recommendations for clinical practice in dermatology
Tue, 04 Nov 2008 05:00:00 +0100 | Dermatologic Surgery
The unit equivalence between the two main Botulinum neurotoxin A (BoNTA) preparations, Dysport (Ipsen Ltd., Slough, Berkshire, UK) and BOTOX (Allergan Inc., Irvine, CA), is a matter of discussion. The UK assay used to test Dysport is more sensitive than the U.S. assay used for BOTOX, resulting in a different efficacy per unit in both formulations. Ratios ranging from 6:1 to 1:1 can be found in the literature, but the more recently published literature suggests that 1 unit of BOTOX is equivalent to approximately 2 to 4 units of Dysport (ratio 2:1[ndash]4:1). Because the number of BoNTA treatments is constantly increasing, these differences warrant a systematic review of published evidence about the unit equivalence of UK and U.S. formulations. The review is based on a detailed literature re...

Comparison of botulinum toxin type a injection and soft-tissue surgery to treat hip subluxation in children with cerebral palsy.
Sat, 01 Nov 2008 04:00:00 +0100 | Archives of Physical Medicine and Rehabilitation
CONCLUSIONS: Comparable effects of BTX-A injection to soft-tissue surgery in our study suggest that BTX-A injection, if timely reinjected, may replace soft-tissue surgery as a prophylactic procedure against progressive hip subluxation or dislocation in children. Age at intervention, functional level, and initial MP before therapeutic intervention were the factors affecting the outcomes. PMID: 18996239 [PubMed - in process] (Source: Archives of Physical Medicine and Rehabilitation)

Long-term use of botulinum toxin type a in children with cerebral palsy: treatment consistency.
Thu, 30 Oct 2008 04:00:00 +0100 | European Journal of Paediatric Neurology
Long-term use of botulinum toxin type A in children with cerebral palsy: Treatment consistency. Eur J Paediatr Neurol. 2008 Oct 30; Authors: Molenaers G, Schörkhuber V, Fagard K, Van Campenhout A, De Cat J, Pauwels P, Ortibus E, De Cock P, Desloovere K At the University Hospital of Pellenberg (Belgium), more than 1000 patients have been treated with Botulinum toxin type A (BTX-A) over the last decade. Ten percent of these patients (n=106) received multiple (at least four times), multi-level, high-dosage treatments. The aim of this study was to evaluate the stability of dosage and treatment intervals in long-term, multi-level, high-dosage treated children with cerebral palsy and to evaluate the evidence for a safe and stable response to this treatment. Data on disease, age,...

For years gaynor suffered chronic sweaty feet - but botox ended her misery
Mon, 27 Oct 2008 23:16:16 +0100 | the Mail online | Health
This summer, Gaynor Carrington splashed out on 12 pairs of new shoes. But the actress and model , 32, was not having an Imelda Marcos moment. (Source: the Mail online | Health)

For years gaynor suffered chronic sweaty feet - but botox ended her misery
Mon, 27 Oct 2008 23:16:16 +0100 | the Mail online | Diet
This summer, Gaynor Carrington splashed out on 12 pairs of new shoes. But the actress and model , 32, was not having an Imelda Marcos moment. (Source: the Mail online | Diet)

Efficacy of botulinum toxin type a in new daily persistent headache
Sat, 25 Oct 2008 08:39:02 +0100 | The Journal of Headache and Pain
Efficacy of botulinum toxin type A in new daily persistent headache Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10194-008-0078-yAuthors Roderick C. Spears, Cleveland Clinic Foundation Center for Headache and Pain 9500 Euclid Avenue T33 Cleveland OH 44195 USA Journal The Journal of Headache and PainOnline ISSN 1129-2377Print ISSN 1129-2369 (Source: The Journal of Headache and Pain)

Study design and methods of the botuls trial: a randomised controlled trial to evaluate the clinical effect and cost effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type a
Thu, 23 Oct 2008 04:00:00 +0100 | BioMed Central
Background: Following a stroke, 55-75% of patients experience upper limb problems in the longer term. Upper limb spasticity may cause pain, deformity and reduced function, affecting mood and independence. Botulinum toxin is used increasingly to treat focal spasticity, but its impact on upper limb function after stroke is unclear. The aim of this study is to evaluate the clinical and cost effectiveness of botulinum toxin type A plus an upper limb therapy programme in the treatment of post stroke upper limb spasticity. Methods: Trial design: A multi-centre open label parallel group randomised controlled trial and economic evaluation. Participants: Adults with upper limb spasticity at the shoulder, elbow, wrist or hand and reduced upper limb function due to stroke more than 1 month previous...

Botulinum toxin type a improves blood flow in vascular thoracic outlet syndrome.
Wed, 22 Oct 2008 15:58:29 +0100 | Medical Physics
Authors: Danielson K, Odderson IR Danielson K, Odderson IR: Botulinum toxin type a improves blood flow in vascular thoracic outlet syndrome. Am J Phys Med Rehabil 2008;87:956-959.A 28-yr-old man, diagnosed with vascular thoracic outlet syndrome, had his right anterior scalene muscle injected with botulinum toxin type A under ultrasound guidance. Subclavian artery flow rates were measured with Doppler ultrasound before and 3 wks after the injection. At 3 wks, symptoms had improved. The reduction in subclavian artery flow rate associated with the arm abducted to the side with 90-degree external rotation decreased from 132.8 to 87.7 cm/sec preinjection compared with a smaller decrease postinjection from 132.8 to 119.1 cm/sec. An improved subclavian artery flow was seen after scalene muscl...

High intensity light reduces facial wrinkles - crystal growth & design
Wed, 22 Oct 2008 09:00:00 +0100 | Dermatology News From Medical News Today
Researchers in Germany are describing a potential alternative to Botox and cosmetic surgery for easing facial wrinkles. Their study, scheduled for the November 5 issue of ACS' Crystal Growth & Design, a bi-monthly journal, reports that high intensity visible light from light emitting diodes (LEDs) applied daily for several weeks resulted in "rejuvenated skin, reduced wrinkle levels, juvenile complexion and lasting resilience. (Source: Dermatology News From Medical News Today)

Failing feet given a botox boost
Tue, 21 Oct 2008 15:44:32 +0100 | Nursing in Practice
After years of tottering around in high heels, fashionistas' feet are being given a new lease of life with Botox (Source: Nursing in Practice)

News from the american chemical society oct. 15, 2008
Tue, 21 Oct 2008 14:00:00 +0100 | Health News from Medical News Today
LEDs may help reduce skin wrinkles, researchers report Researchers in Germany are describing a potential alternative to Botox and cosmetic surgery for easing facial wrinkles. (Source: Health News from Medical News Today)

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